Stroke-Biomarkers.com

78

Q15848

Adiponectin, ARCP30, gelatin-binding protein

ADIPO

ADIPOQ

9370

http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADIPOQ

Adipokine hormone controlling fat metabolism and insulin sensitivity, with anti-diabetic, anti-atherogenic and anti-inflammatory activities. Antagonist of TNF-a. Inhibits endothelial NF-kB signaling.

No

false

Secreted

false

Plasma, Serum

false

Yes



Unknown

false

Unknown

false

Yes



It forms multimers, with different activities. Adiponectin has a pharmaceutical use in the treatment of diabetes mellitus type 2 and insulin resistance. Higher circulating levels in females, maybe due to different multimer forms [1].

1. Arita Y et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999, 257(1):79-83.

Higher adiponectin circulating levels are associated with functional disability 3 months after stroke and cardioembolic etiology. Adiponectin is related with increased risk of ischemic stroke and improves net reclassification using multivariable predicting models.



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Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.