Stroke-Biomarkers.com

44

Q15109

Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

RAGE

AGER

177

http://www.genecards.org/cgi-bin/carddisp.pl?gene=AGER&search=sRAGE

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.RAGE

Vessel

false

Membrane, Secreted

false

Plasma, Serum

false

Unknown

false

Unknown

false

Unknown

false

Unknown

false

-

-

RAGE has been associated with ischemic stroke, and it may be a plasma biomarker to differenciate ischemic from hemorrhagic stroke. Ischemic stroke patients present raised plasma levels than hemorrhagic stroke patients.

Inflammatory response

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.