LDL-associated phospholipase A2
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques.
TBA1A, ESR1, GRID2, CHPT1, IGF1
cAMP-Dependent PKA; PAK ,PTEN, PKC-Theta
The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and seems to be closely correlated to cardiovascular events.
Miklishanskaia SV et al. Clinical role of lipoprotein-associated phospholipase A2.Kardiologiia. 2013;53(3):59-70;
Fontes JD et al. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study..Atherosclerosis. 2013 May;228(1):217-23;
Delgado P. et al.Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients. J.Cerebrovasc Dis. 2012;33(2).
Lipoprotein associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker which provides information on plaque inflammation and stability. Data from epidemiological studies have shown that is a risk factor for primary and secondary ischemic stroke.