Stroke-Biomarkers.com

28

Q13093

LDL-associated phospholipase A2

PAFA

PLA2G7

GC06M046719

http://www.genecards.org/cgi-bin/carddisp.pl?gene=PLA2G7&search=PLA2G7

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques.

No

false

Secreted

false

Plasma, Serum

false

Yes

TBA1A, ESR1, GRID2, CHPT1, IGF1

Unknown

false

Yes



Yes

cAMP-Dependent PKA; PAK ,PTEN, PKC-Theta

The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and seems to be closely correlated to cardiovascular events.

Miklishanskaia SV et al. Clinical role of lipoprotein-associated phospholipase A2.Kardiologiia. 2013;53(3):59-70; Fontes JD et al. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study..Atherosclerosis. 2013 May;228(1):217-23; Delgado P. et al.Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients. J.Cerebrovasc Dis. 2012;33(2).

Lipoprotein associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker which provides information on plaque inflammation and stability. Data from epidemiological studies have shown that is a risk factor for primary and secondary ischemic stroke.

Lipid metabolism

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.