Stroke-Biomarkers.com

46

P42574

Caspase-3, Apopain, Cysteine protease CPP32

CASP3

CASP3

836

http://www.genecards.org/cgi-bin/carddisp.pl?gene=CASP3&search=caspase3

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage

Unknown

false

Cytoplasm

false

Plasma, Serum, Saliva, CSF

false

Unknown

false

Yes



Unknown

false

Unknown

false

-

-

Downregulation of caspase-3 is associated with reduced brain damage in ischemic models. CASP3 is more elevated in stroke than mimics. Similar levels have been determined in both subtypes of stroke during acute phase.

Apoptosis

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.