Biomarker function:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage
Body fluids:Plasma, Serum, Saliva, CSF
Associations:Downregulation of caspase-3 is associated with reduced brain damage in ischemic models. CASP3 is more elevated in stroke than mimics.
Similar levels have been determined in both subtypes of stroke during acute phase.