Matrix metalloproteinase-9, Gelatinase B
Role in local proteolysis of the extracellular matrix and in leukocyte migration. Cleaves type IV and type V collagen. Degrades fibronectin but not laminin.
Plasma, Serum, CSF
Its proteolytic action over the extracellular matrix is related with angiogenesis processes.
Associated with BBB disruption. Positively correlated with stroke severity and infart volume within acute phase of ischemic stroke. Raised plasma MMP-9 in stroke patients than mimics. Its relationship with poor outcome is not clear.
Similar levels have been determined in both subtypes of stroke during acute phase.