- Synonyms:Procalcitonin, Calcitonin gene-related peptide I (CGRP-I), Alpha-type CGRP.
- Biomarker name:CALCA
- Gene name:CALCA
- Gene id:796
- Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALCA&search=procalcitonin
- Biomarker function:CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
- Neurovascular unit:No
- Intracellular location:Cytoplasm, Secreted
- Body fluids:Plasma, Serum
- Prot-prot interactions:Yes: CALCRL, ECE1, BBS4, BBS1
- Signaling pathway:Yes: Signal Transduction
- Biological process:Angiogenesis, Biomineralization, Cell adhesion, Cytokinin biosynthesis, Cytokinin signaling pathway, Osteogenesis
- Comments:Peptide precursor of the hormone Calcitonin. It is composed by 116 aminoacids and produed by parafollicular cells of the thyroid and by the neuroendocrine cells of the lungs and intestine. The level of PCT in the blood stream of healthy individuals is blow the limit of detection (10 pg/mL) of clinical assays. The level raises in response to proinflammatory stumulus, especially of bacterial origin.
- Associations:Procalcitonin is used in clinical practise as a marker of bacterial infections. In stroke, it has been described as a predictor os stroke-associated infections.
Source articles by endpoint
|Infection||Hug A., 2011; Fluri, F, 2012;|