Stroke-Biomarkers.com

34

P06881

Procalcitonin, Calcitonin gene-related peptide I (CGRP-I), Alpha-type CGRP.

CALCA

CALCA

796

http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALCA&search=procalcitonin

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

No

false

Cytoplasm, Secreted

false

Plasma, Serum

false

Yes

CALCRL, ECE1, BBS4, BBS1

Unknown

false

Unknown

false

Yes

Signal Transduction

Peptide precursor of the hormone Calcitonin. It is composed by 116 aminoacids and produed by parafollicular cells of the thyroid and by the neuroendocrine cells of the lungs and intestine. The level of PCT in the blood stream of healthy individuals is blow the limit of detection (10 pg/mL) of clinical assays. The level raises in response to proinflammatory stumulus, especially of bacterial origin.

-

Procalcitonin is used in clinical practise as a marker of bacterial infections. In stroke, it has been described as a predictor os stroke-associated infections.

Angiogenesis, Biomineralization, Cell adhesion, Cytokinin biosynthesis, Cytokinin signaling pathway, Osteogenesis

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.