Stroke-Biomarkers.com

29

P05231

Interleukin-6, BSF-2, CDF, IFN-beta2

IL6

IL6

3569

http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL6&search=il6

Cytokine that induces the acute phase response, plays an essential role in the differentiation of different leukocytes and other cells and acts to increase the breakdown of fats and to improve insulin resistance.

No

false

Secreted

false

Plasma, Serum, CSF

false

Yes



Unknown

false

Unknown

false

Yes



Dual role, pro- and anti-inflammatory (by inhibition of TNF-a, IL-1 and activation of IL-10) [1]. IL6 crosses the blood brain barrier. It is also secreted after muscle contraction (anti-inflammatory myokine).

1. Scheller J et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011, 1813(5):878-88.

IL6 has been studied in stroke patients regarding stroke incidence, recurrence and prognosis and higher levels of IL6 have been associated with all of these endpoints. It has also been proposed as a predictor of infections. No significant association has been found between IL6 levels and aetiological subtypes of ischemic stroke

Acute phase

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.