Biomarker function:Blood glycoprotein involved in the maintenance of hemostasis by adhering platelets to the sites of vascular injury. Chaperone for coagulation factor VIII.
Neurovascular unit:Vessel, Extracellular matrix
Body fluids:Plasma, Serum, Urine, CSF
Biological process:Cell adhesion, Hemostasis
Comments:Defects on VWF protein result in impaired platelet aggregation, leading to hemorrhages (von Willebrand disease).
Associations:Higher circulating levels in stroke patients with functional disability at third month after the event. No significant association has been found between vWf levels and aetiological classification of ischemic stroke