Biomarker function:Role in iron homeostasis, storing iron and delivering it to cells. In that way, Ferritin avoids iron toxicity and the formation of free radicals.
Neurovascular unit:Microglia, Other:
Body fluids:Plasma, Serum
Biological process:Acute phase, Iron storage
Comments:Ferritin stands as an spherical oligomer, having light and heavy chains. Genetic mutations in FTL gene cause a neurodegenerative disorder associated with iron accumulation . Ferritin concentration increase in the presence of infection  and hypoxia .
Associations:In stroke, high ferritin levels have been associated with hemorrhagic transformation and outcome.
References:1. Maciel P et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010, 285:11948-57.
2. Krol V et al. Diagnostic significance of serum ferritin levels in infectious and non-infectious diseases. Infect Dis Pract. 2003, 27:199-200.
3. Qi Y et al. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem. 1995, 64(6):2458-64.