Stroke-Biomarkers.com

72

P02792

Ferritin

FRIL

FTL

2512

http://www.genecards.org/cgi-bin/carddisp.pl?gene=FTL

Role in iron homeostasis, storing iron and delivering it to cells. In that way, Ferritin avoids iron toxicity and the formation of free radicals.

Microglia, Other



Cytoplasm

false

Plasma, Serum

false

Yes



Yes



Yes



Unknown

false

Ferritin stands as an spherical oligomer, having light and heavy chains. Genetic mutations in FTL gene cause a neurodegenerative disorder associated with iron accumulation [1]. Ferritin concentration increase in the presence of infection [2] and hypoxia [3].

1. Maciel P et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010, 285:11948-57. 2. Krol V et al. Diagnostic significance of serum ferritin levels in infectious and non-infectious diseases. Infect Dis Pract. 2003, 27:199-200. 3. Qi Y et al. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem. 1995, 64(6):2458-64.

In stroke, high ferritin levels have been associated with hemorrhagic transformation and outcome.

Acute phase, Iron storage

public

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2020. Last update: 2018-02-02 14:48:58h.