Role in iron homeostasis, storing iron and delivering it to cells. In that way, Ferritin avoids iron toxicity and the formation of free radicals.
Ferritin stands as an spherical oligomer, having light and heavy chains. Genetic mutations in FTL gene cause a neurodegenerative disorder associated with iron accumulation . Ferritin concentration increase in the presence of infection  and hypoxia .
1. Maciel P et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010, 285:11948-57.
2. Krol V et al. Diagnostic significance of serum ferritin levels in infectious and non-infectious diseases. Infect Dis Pract. 2003, 27:199-200.
3. Qi Y et al. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem. 1995, 64(6):2458-64.
In stroke, high ferritin levels have been associated with hemorrhagic transformation and outcome.
Acute phase, Iron storage