Biomarker function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Body fluids:Plasma, Serum, CSF
Biological process:Inflammatory response
Associations:Cytokines may contribute to both neurotoxicity and neuroprotection. IL1beta has been found elevated in ischemic stroke patients compared to mimics. No clear association has been found with aetiological classification of ischemic stroke