- Biomarker name:Homocysteine
- Gene name:-
- Gene id:-
- Genecards link:http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=778
- Biomarker function:Homocysteine is a non-protein aminoacid which must be biosynthesized from methionine.
- Neurovascular unit:Unknown
- Intracellular location:Unknown
- Body fluids:Plasma, Serum, Urine
- Prot-prot interactions:Unknown
- Signaling pathway:Unknown
- Biological process:
- Comments:Hyperhomocysteinemia is related to endothelial injury , as it is involved in degradation and inhibition of formation of collagen, elastin and proteoglycans. Hyperhomocysteinemia can be treated with vitamins supplementation. Higher HCY levels in men and in the elderly.
- Associations:Hyperhomocysteinemia is associated with death after stroke. Its association with long-term disability is not clear.No clear association has been found between homocysteine levels and aetiological classification of ischemic stroke
- References:1. Jin L et al. Homocysteine induces endothelial dysfunction via inhibition of arginine transport. J Physiol Pharmacol. 2007, 58(2):191-206.
Source articles by endpoint
|Disability||Tu WJ, 2013;|
|Exitus||Tu WJ, 2013; Üstündağ M, 2010;|
|Worsening||Men X, 2013;|